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Inference of stem cell and tissue dynamics in development and regeneration
The dynamics of a tissue in development or regeneration arises from the behaviour of its constituent cells and their interactions. We use mathematical models and inference from experimental data to to infer the likely cellular behaviours underlying changing tissue states. In this talk I will show examples of how we apply canonical birth-death process models to novel experimental data, how we are extending such models with volume exclusion and multistate dynamics, and how we attempt to more generally learn cell-cell interaction models directly from data in interpretable ways. The applications range from in vitro models of embryo development to in vivo blood regeneration that is disrupted with ageing.
Date:
10 February 2023, 14:00
Venue:
Mathematical Institute, Woodstock Road OX2 6GG
Venue Details:
L3
Speaker:
Dr Linus Schumacher (University of Edinburgh)
Organising department:
Mathematical Institute
Organiser:
Sara Jolliffe (University of Oxford)
Organiser contact email address:
sara.jolliffe@maths.ox.ac.uk
Host:
Dr Peter Minary (University of Oxford)
Part of:
Mathematical Biology and Ecology
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sara Jolliffe
