Nucleic Acid Sensing by Innate Immune Receptors
The innate immune response is critical for successful host defence against virus infection. Cell-intrinsic mechanisms detect virus presence and restrict virus replication. Nucleic acids are often a molecular signature of virus infection and are recognised by innate receptors including toll-like receptors, RIG-I-like receptors and cytosolic DNA sensors. These receptors signal for the induction of innate response genes such as those encoding type I interferons. These in turn induce the expression of restriction factors, host proteins that limit virus replication.
Our work focuses on cytosolic nucleic acid sensors, in particular RIG-I, MDA5 and cGAS. We are also studying the restriction factor SAMHD1. We are using in vitro and in vivo models of virus infection (including influenza A virus, retroviruses and varicella-zoster virus) and are interested in Aicardi-Goutières syndrome, a rare genetic disease linked to chronic anti-viral innate immune responses. In this presentation, I will discuss our recent work on cGAS and other nucleic acid sensors.
Date: 16 July 2018, 12:00 (Monday, 13th week, Trinity 2018)
Venue: Bernard Sunley Lecture Theatre
Speaker: Prof Jan Rehwinkel ((Radcliffe Department of Medicine) University of Oxford)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Laura Sánchez Lazo (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology), Jo Silva (NDORMS), Wulf Forrester-Barker (University of Oxford, Nuffield Dept of Orthopaedics Rheumatology and Musculoskeletal Sciences)
Host: Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Laura Sanchez Lazo