Nucleic Acid Sensing by Innate Immune Receptors
The innate immune response is critical for successful host defence against virus infection. Cell-intrinsic mechanisms detect virus presence and restrict virus replication. Nucleic acids are often a molecular signature of virus infection and are recognised by innate receptors including toll-like receptors, RIG-I-like receptors and cytosolic DNA sensors. These receptors signal for the induction of innate response genes such as those encoding type I interferons. These in turn induce the expression of restriction factors, host proteins that limit virus replication.
Our work focuses on cytosolic nucleic acid sensors, in particular RIG-I, MDA5 and cGAS. We are also studying the restriction factor SAMHD1. We are using in vitro and in vivo models of virus infection (including influenza A virus, retroviruses and varicella-zoster virus) and are interested in Aicardi-Goutières syndrome, a rare genetic disease linked to chronic anti-viral innate immune responses. In this presentation, I will discuss our recent work on cGAS and other nucleic acid sensors.
16 July 2018, 12:00 (Monday, 13th week, Trinity 2018)
Kennedy Institute of Rheumatology, Headington OX3 7FY
Bernard Sunley Lecture Theatre
Prof Jan Rehwinkel ((Radcliffe Department of Medicine) University of Oxford)
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Laura Sánchez Lazo (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology),
Jo Silva (NDORMS),
Wulf Forrester-Barker (University of Oxford, Nuffield Dept of Orthopaedics Rheumatology and Musculoskeletal Sciences)
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Kennedy Institute Seminars
Members of the University only
Laura Sanchez Lazo