Exploring the spatial pathobiology of cAMP signaling
John Scott has been instrumental in defining of how second messenger signaling event are compartmentalized within the cell. Through his discovery of the A-Kinase Anchoring protein family, he has shown how protein kinases, phosphatases and phosphodiesterases are constrained within second messenger nanodomains. He will discuss the discovery and investigation of new disease causing mutations in PKA and AKAPs that underlie Adrenal Cushing’s syndrome and adolescent liver cancers.
Date: 2 November 2022, 13:00 (Wednesday, 4th week, Michaelmas 2022)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Florence Buchanan Lecture Theatre (second floor)
Speaker: John D. Scott FRS (Edwin G. Krebs-Speights Professor of Cell Signaling and Cancer Biology, Department of Pharmacology, University of Washington School of Medicine, Seattle)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Professor Manuela Zaccolo MD (DPAG, University of Oxford)
Organiser contact email address: manuela.zaccolo@balliol.ox.ac.uk
Host: Professor Manuela Zaccolo MD (DPAG, University of Oxford)
Part of: Cell Physiology Theme Guest Speakers (DPAG)
Booking required?: Not required
Audience: Members of the University only
Editor: Talitha Smith