OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Arterial spin labelling (ASL) MRI is a non-invasive method for the quantitation of blood flow by imaging the effects of in-flowing magnetically tagged blood on tissue water in a region of interest. In 2015, guidelines for clinical use of ASL were proposed, however, these were still lacking in pre-clinical settings. Moreover, dysregulated cerebral blood flow is a component of many diseases including brain tumours. Therefore, our initial aims were to optimise pre-clinical ASL in rats to obtain quantitative measurements of cerebral blood flow and to apply this methodology to a model of brain metastasis to examine the perfusion changes that occur in this disease setting. Additionally, we wished to determine if ASL could be used as an alternative to dynamic contrast enhanced (DCE) MRI in assessing treatment outcome with vascular normalising agents such as bevacizumab (Avastin®), as it requires no exogenous contrast agents.
