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Regulation of protein synthesis and proteostasis by the Integrated Stress Response’
The regulated phosphorylation and de-phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2) potently regulates global and gene-specific mRNA translation and thereby broadly affects proteostasis in diverse physiological and pathological settings. Phosphorylated eIF2 is a convergence point for several stress response pathways and its downstream effector processes are known as the integrated stress response (or ISR). In this talk I will review recent advances in our understanding of the ISR and its role in proteostasis.
Date:
23 November 2023, 16:00
Venue:
Sherrington Building
Speaker:
Professor David Ron (University of Cambridge)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Prof David Paterson (University of Oxford)
Organiser contact email address:
communications@dpag.ox.ac.uk
Host:
Prof David Paterson (University of Oxford)
Part of:
John Scott Haldane Prize Lecture
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Peter Belk
