Towards a tissue-level understanding of homeostasis and inflammation
In-person only
Immune responses unfold within tissues whose architecture and composition fundamentally shape inflammation and its resolution. Understanding these processes requires integrating spatial tissue structure with cellular dynamics and function. In this seminar, we will explore advanced imaging and computational approaches that connect single-cell behavior with tissue-level organization. By combining multiplex 3D microscopy, quantitative analysis, and in vivo functional imaging, we examine how tissue macrophages interact with stromal networks to sustain homeostasis or promote dysfunction. Through this framework, we will discuss how spatial tissue organization may set local inflammation thresholds and govern the shift from physiological repair to pathological disease.
Date: 10 December 2025, 12:00
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Kennedy Lecture Theatre
Speaker: Prof Dr med Stefan Uderhardt (University Hospital Erlangen)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Tess Lawless (Kennedy Institute of Rheumatology), Katie Roberts (University of Oxford)
Host: Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Katie Roberts