T cell immunity begins with TCR allosteric activation
T cell-dependent immunity commences with T-cell antigen receptor (TCR-CD3) signalling. TCR-CD3 features unique ligand recognition, signalling modalities and convoluted quaternary structure, diverging considerably from “classic”, evolutionary ancient membrane receptors of simpler molecular design and univocal relationship to ligands. TCR-CD3 recognises with exceptional sensorial and discriminatory ability antigens of varying structure, quantity and detection context. Given such a complexity, it is perhaps unsurprising that controversy exists on how TCR-CD3 works. I will report new data suggesting an allosteric mechanism by which TCR-CD3 transmits signals across the plasma membrane that should improve our understanding of how T cell activation begins.
Date: 9 December 2019, 12:00 (Monday, 9th week, Michaelmas 2019)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Professor Oreste Acuto (University of Oxford )
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser: Jennifer Pope (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Dr Marco Fritzsche (University of Oxford)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Public
Editor: Jennifer Pope