OxTalks is Changing
OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected in early Hilary to allow all events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed as soon as possible.
If you have any questions, please contact halo@digital.ox.ac.uk
T cell immunity begins with TCR allosteric activation
T cell-dependent immunity commences with T-cell antigen receptor (TCR-CD3) signalling. TCR-CD3 features unique ligand recognition, signalling modalities and convoluted quaternary structure, diverging considerably from “classic”, evolutionary ancient membrane receptors of simpler molecular design and univocal relationship to ligands. TCR-CD3 recognises with exceptional sensorial and discriminatory ability antigens of varying structure, quantity and detection context. Given such a complexity, it is perhaps unsurprising that controversy exists on how TCR-CD3 works. I will report new data suggesting an allosteric mechanism by which TCR-CD3 transmits signals across the plasma membrane that should improve our understanding of how T cell activation begins.
Date:
9 December 2019, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Professor Oreste Acuto (University of Oxford )
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Jennifer Pope (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Dr Marco Fritzsche (University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Public
Editor:
Jennifer Pope
