HIFα under pressure
Vascular pressure in vertebrates is regulated by a range of factors; one key element of control is peripheral resistance in tissue capillary beds. I have explored in two independent vascular beds how a hypoxic response via HIF transcription factors influences cardiovascular function. These data indicate that independent tissues and their vascular beds form a complex physiological network of oxygen-responsive tissues that have the ability to influence, and not just be influenced by central regulators of cardiovascular function. This interaction amongst tissues indicates that cardiovascular response to hypoxia is likely the summation from a range of tissue responses, and not solely driven by central mediators of cardiovascular activity.
Date:
31 October 2017, 12:00 (Tuesday, 4th week, Michaelmas 2017)
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Library
Speaker:
Dr Andrew Cowburn (University of Cambridge)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Sally Collins (University of Oxford)
Organiser contact email address:
hod-pa@dpag.ox.ac.uk
Hosts:
Professor Keith Dorrington (University of Oxford),
Professor Peter Robbins (DPAG, University of Oxford)
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sally Collins
