Quantitative Approaches Towards Understanding Multicellular Organisation and Communication
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJUvc-6hrT8oGNUvBHRYE_dYudaz8bR0Fa7l
Multicellular organisation requires the coordination of multiple signalling pathways that regulate cell shape as well as cell-cell and cell-microenvironment interactions. Such coordination is often lost in cancer resulting in changes in tissue architecture, uncontrolled growth, and metastasis. Imaging technologies provide a powerful approach to simultaneously study the signalling and organisational state of cells. I will discuss the development of machine learning and computer vision methodologies for automated identification of genetic programmes underlying tissue organisation. Importantly, these studies reveal that cell context and shape can modulate cell signalling even in isogenic cell cultures. Using orthogonal datasets and integrative approaches, we validate the clinical relevance of cell shape and context in patient prognosis.
Date: 7 October 2020, 10:00 (Wednesday, 0th week, Michaelmas 2020)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJUvc-6hrT8oGNUvBHRYE_dYudaz8bR0Fa7l
Speaker: Dr Heba Sailem (University of Oxford)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Professor Mike Dustin (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://zoom.us/meeting/register/tJUvc-6hrT8oGNUvBHRYE_dYudaz8bR0Fa7l
Audience: Public
Editor: Jennifer Pope