OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Reducing waste and increasing value in experimental biomedicine
Recent advances in biomedical research provide innumerable opportunities to develop novel preventive and therapeutic strategies. However, only a small fraction of biomedical discoveries are successfully translated into clinical applications. Potential ‘breakthrough’ therapies, which are spectacularly successful in animal models of disease, often fail in clinical trials. This translational bottleneck imposes burdens on research and healthcare systems, as well as patients who participate in trials of novel strategies. The high attrition rate of preclinical to clinical development may directly relate to concerns about the reliability and reproducibility of biomedical research. Apparently there are substantial weaknesses in planning, conducting, analysing, and reporting this research. Low internal and external validity as well as low statistical power in particular of preclinical research appears to produce a very high rate of false positives, and inflates effect sizes unrealistically. Not surprisingly then, the majority of scientists believe that we are in the midst of a ‘reproducibility crisis’. The immense proliferation in research outputs, combined with increasing methodological complexity and the size of data sets, greatly complicates the sharing, evaluation, and synthesis of high quality evidence. At the same time, nonpublication of results leads to duplicative research and deprives medical decision-makers of the totality of evidence. But how can we overcome this crisis?
In my presentation I will present a set of behaviours, activities and research practices, some of which may be relevant to your own work and which present prime targets for improvement
Date:
21 September 2021, 9:00
Venue:
Venue to be announced
Speaker:
Prof Dr Uli Dirnagl (Charité, Berlin)
Organiser:
Dr Malika Ihle (University of Oxford)
Part of:
Oxford|Berlin summer school on Open Research
Booking required?:
Required
Booking url:
https://www.eventbrite.com/e/lectures-of-the-oxfordberlin-summer-school-on-open-research-2021-tickets-164864292537
Cost:
free
Audience:
Public
Editor:
Malika Ihle
