Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Cancer cells display heterogeneous and dynamic states in glioblastoma, but how these malignant states arise and whether they follow a tractable cellular trajectory across tumours is poorly understood. Here, we generate a deep single cell and spatial multi-region atlas of glioblastoma that integrates transcriptomic, epigenomic and genomic analysis to comprehensively characterise their tumour heterogeneity. We describe spatially-patterned transitions of malignant cells from dev-like towards glial injury response- and hypoxia-defined states during tumour expansion. This malignant cell trajectory dominates glioblastoma, manifesting across tumours and genetically distinct subclonal lineages that are finely spatially intermixed within tumours. Moreover, this trajectory unfolds across specialised myeloid signalling environments that mirror the spatial compartmentalization of malignant cells. Our findings define a stereotyped trajectory of cancer cells in glioblastoma and unify glioblastoma tumour heterogeneity into a tractable cellular and tissue framework.
