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Engineering and Safeguarding Synthetic Genomes
Over the last 12 years, my lab has been building synthetic yeast chromosomes from scratch. These synthetic genomes are engineered to allow genome-wide directed evolution with a system call SCRaMbLE (Synthetic Chromosome Recombination and Modification by LoxP-Mediated Evolution). SCRaMbLE allows the synthetic cells to process the information (e.g. environmental stress) differently from their wildtype counterparts, and also enables them to re-configure the genomes to cope with the environments. I will present our latest progress in design, synthesis and transplant synthetic chromosomes and its applications. Finally, I will also discuss the progress of developing biocontainment strategies for synthetic genomes.
Date:
6 March 2026, 14:00
Venue:
Medical Sciences Teaching Centre, off South Parks Road OX1 3PL
Venue Details:
Lecture Theatre
Speaker:
Prof Patrick Cai (University of Manchester)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Melissa Wright (Sir William Dunn School of Pathology)
Organiser contact email address:
melissa.wright@path.ox.ac.uk
Host:
Prof Matthew Freeman (Dunn School of Pathology)
Part of:
Dunn School of Pathology Departmental Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Melissa Wright
