OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Thalamus drives coupling of information streams in cortical dendrites
Perception is linked to a calcium-dependent spiking mechanism that is built into the distal dendrites of layer 5 pyramidal tract neurons (L5PTs) – the major output cell type of the cerebral cortex. It is yet unclear which circuits activate this cellular mechanism upon sensory stimulation. Here we found that the same thalamocortical axons that relay sensory signals to layer 4 also densely target the dendritic domain by which pyramidal tract neurons initiate calcium spikes. Distal dendritic inputs, which normally appear greatly attenuated at the cell body, thereby generate bursts of action potentials in cortical output upon stimulus onset. Our findings indicate that thalamus drives an active dendritic mechanism to couple sensory signals with top-down information streams into cortical output. Thus, in addition to being the central hub for sensory signals, thalamus is also likely to ensure that the signals it relays to cortex are perceived by the animal.
Date:
16 May 2023, 11:00
Venue:
Sherrington Library, off Parks Road OX1 3PT
Speaker:
Dr Arco Bast (Lab of Marcel Oberlaender, MPI for Neurobiology of Behavior, Germany)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Professor Randy Bruno (DPAG, University of Oxford)
Organiser contact email address:
randy.bruno@dpag.ox.ac.uk
Host:
Professor Randy Bruno (DPAG, University of Oxford)
Part of:
Neuroscience Theme Guest Speakers (DPAG)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Talitha Smith
