Development of haematopoietic stem cells: from cellular hierarchy to molecular mechanisms
Haematopoietic stem cells (HSCs) develop in the aorta-gonad-mesonephros (AGM) region. In utero development significantly reduces accessibility of the mouse embryo for analysis. We established AGM in vitro systems that can recapitulate in vivo HSC development, which allowed us to reconstruct and functionally validate the hierarchical organisation of HSC development. The first HSCs emerge in small numbers, possess an enormous regenerative/ self-renewing potential and can generate hundreds of fully functional daughter HSCs. We revealed a highly heterogeneous signalling landscape that can regulate HSC development in a concerted manner. In this talk, commonalities and differences in mouse and human development will be discussed.
Date: 20 May 2019, 12:00
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Prof Alexander Medvinsky (Institute for Stem Cell Research, Edinburgh)
Organising department: Kennedy Institute of Rheumatology
Organiser: Dr Anjali Kusumbe (Kennedy Institute of Rheumatology)
Organiser contact email address: fiona.silby@tss.ox.ac.uk
Host: Dr Anjali Kusumbe (Kennedy Institute of Rheumatology)
Booking required?: Not required
Audience: Members of the University only
Editor: Fiona Silby