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The genomic compass of cell fate: how aneuploidy impacts the first week of human development
Abstract:
Human embryos are remarkably prone to mitotic errors during their first days of development: up to 70% carry genetically abnormal cells by the third day. In the first part of this seminar, I will cover the journey we all made from a chaotic genetic content to a (mostly) normal genome, summarizing what we know on how we manage this feat. In the second half, I will move on to human embryonic stem cells, the in vitro counterpart of the inner cell mass – the part of the embryo that becomes the fetus. Embryonic stem cells are also prone to genomic instability, which my lab studies from multiple angles. In this talk, I will present some of the work we do, and show you the opportunities these abnormalities provide to discover gene function in cell fate specification, during a window of human development otherwise inaccessible.
Date:
11 April 2024, 14:00
Venue:
This event is hybrid
Speaker:
Professor Claudia Spits (Vrije Universiteit Brussel)
Organising department:
Nuffield Department of Women's and Reproductive Health
Organisers:
Michael Suttie (NDWRH, University of Oxford),
Dr Lydia Coxon (NDWRH, University of Oxford)
Organiser contact email address:
seminars@wrh.ox.ac.uk
Host:
Prof Jo Poulton (Nuffield Department of Women's & Reproductive Health, University of Oxford )
Booking required?:
Recommended
Booking email:
seminars@wrh.ox.ac.uk
Audience:
Members of the University only
Editor:
Isobel Way
