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Role of the BRCA2-DSS1 Complex in Homologous Recombination
The exchange of the DNA binding protein RPA for the RAD51 recombinase on single-stranded DNA is a critical step in DNA break repair by homologous recombination. This RPA-RAD51 handoff is dependent on the tumor suppressor BRCA2. Importantly, our work has shown that the BRCA2-associated DSS1, a small, highly acidic protein, is also needed for this handoff process. Mechanistically, DSS1 acts as a DNA mimic to attenuate the affinity of RPA for DNA. Thus, by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance.
Date:
30 November 2015, 15:00
Venue:
Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details:
Main Seminar Room
Speaker:
Professor Patrick Sung (Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology, Yale University)
Organising department:
Department of Biochemistry
Organiser:
Professor Matthew Whitby (Department of Biochemistry)
Organiser contact email address:
matthew.whitby@bioch.ox.ac.uk
Part of:
Seminar
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Julian Jordan,
Sarah-Jane Scard
