Targeting immunosenescence to enhance immunity
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJ0kde6tpjsvH9O97U8PRl0Dn9BFEaUlgqnO
The Akbar group has identified multiple novel mechanisms that induce immune decline during ageing. They discovered a new inhibitory protein complex in aged T cells that is regulated by sestrins, which can be blocked to enhance vaccine responsiveness in mice. In addition they showed that defective immunity to viruses in the skin of old humans arises from excessive inflammation, that could be reversed by treatment with an anti-inflammatory p38 MAPkinase inhibitor in vivo. This Showed unequivocally that immune decline can be reversed during ageing both at the cellular level and in respoinse to antigen challenge in vivo. This has considerable implications for strategies to enhance immunity after severe infections and vaccination that are reduced during ageing.
Date: 29 March 2021, 12:00 (Monday, 11th week, Hilary 2021)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJ0kde6tpjsvH9O97U8PRl0Dn9BFEaUlgqnO
Speaker: Prof Arne Akbar (University College London)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Prof Chris Buckley (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://zoom.us/meeting/register/tJ0kde6tpjsvH9O97U8PRl0Dn9BFEaUlgqnO
Audience: Public
Editor: Jennifer Pope