“Visualizing the conformational dynamics of viral membrane fusion machines".
Influenza hemagglutinin (HA) is the canonical type-I viral envelope glycoprotein, and provides a template for the membrane fusion mechanisms of numerous viruses. Here, using single-molecule Förster resonance energy transfer (smFRET) imaging we directly visualized conformational changes of HA trimers on the viral surface. These findings reveal the coordination between receptor binding and HA conformational dynamics, which facilitates efficient fusion.
3 May 2018, 13:00 (Thursday, 2nd week, Trinity 2018)
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Meeting room A
Asst. Prof James Munro (Tufts School of Medicine, Boston)
Wellcome Trust Centre for Human Genetics
Agata Krupa (Wellcome Centre for Human Genetics, University of Oxford)
Dr Sergi Padilla Parra (University of Oxford)
Members of the University only