“Visualizing the conformational dynamics of viral membrane fusion machines".
Influenza hemagglutinin (HA) is the canonical type-I viral envelope glycoprotein, and provides a template for the membrane fusion mechanisms of numerous viruses. Here, using single-molecule Förster resonance energy transfer (smFRET) imaging we directly visualized conformational changes of HA trimers on the viral surface. These findings reveal the coordination between receptor binding and HA conformational dynamics, which facilitates efficient fusion.
Date: 3 May 2018, 13:00 (Thursday, 2nd week, Trinity 2018)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Meeting room A
Speaker: Asst. Prof James Munro (Tufts School of Medicine, Boston)
Organising department: Wellcome Trust Centre for Human Genetics
Organiser: Agata Krupa (Wellcome Centre for Human Genetics, University of Oxford)
Host: Dr Sergi Padilla Parra (University of Oxford)
Part of: Strubi seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Agata Krupa