Follicular Dendritic Cells Spill the Transcriptomic Tea
No virtual option for this seminar
Stromal-derived Follicular Dendritic Cells (FDCs) are indispensable for the orchestration of germinal centers (GCs), the epicenter of B cell antibody maturation. Despite their pivotal role, the transcriptome of human FDCs remains an enigma. Leveraging single-cell RNA sequencing and microarray analyses, we present a comprehensive transcriptomic portrait of these elusive cells, validated through flow cytometry and microscopy. This has led to surprising insights and new study directions, which I will discuss. Perhaps there is more regulation in de GC than we thought.
Date: 15 January 2024, 12:00
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Dr Balthasar Heesters (Utrecht University - The Netherlands)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser: Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address: doris.chan@kennedy.ox.ac.uk
Host: Joannah Fergusson (University of Oxford)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Doris Chan