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Follicular Dendritic Cells Spill the Transcriptomic Tea
No virtual option for this seminar
Stromal-derived Follicular Dendritic Cells (FDCs) are indispensable for the orchestration of germinal centers (GCs), the epicenter of B cell antibody maturation. Despite their pivotal role, the transcriptome of human FDCs remains an enigma. Leveraging single-cell RNA sequencing and microarray analyses, we present a comprehensive transcriptomic portrait of these elusive cells, validated through flow cytometry and microscopy. This has led to surprising insights and new study directions, which I will discuss. Perhaps there is more regulation in de GC than we thought.
Date:
15 January 2024, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Balthasar Heesters (Utrecht University - The Netherlands)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Joannah Fergusson (University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
