Recording tumour-immune communication through interaction-based labeling in vivo
In-person only
Recording cell–cell interactions in vivo and isolating live interacting cell partners for downstream analysis holds immense potential for understanding how the immune system engages with tumours. Application of LIPSTIC (Labelling Immune Partnerships by SorTagging Intercellular Contacts) in tumour-bearing models has revealed a previously uncharacterised subpopulation of dendritic cells (DCs). These DCs engage directly with T cells, display a distinct transcriptomic signature, and possess enhanced T cell priming capacity. Notably, this subset also shows heightened responsiveness to immune checkpoint blockade therapy, underscoring its critical role in shaping effective anti-tumour immunity. As tumour–immune interactions can also promote immunosuppression, ongoing work employs LIPSTIC to map the tumour–immune interactome, offering insights into immune evasion and guiding strategies to enhance anti-tumour responses.
Date:
9 June 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Aleksey Chudnovskiy (Francis Crick Institute)
Organising department:
Kennedy Institute of Rheumatology
Organiser:
Magdalena Gross
Hosts:
Dr Audrey Gerard (The Kennedy Institute of Rheumatology),
Dr Tal Arnon (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Magdalena Gross
