Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Eukaryotic cells sense and decode chemical and mechanical signals via plasma membrane receptors such as integrins. Evidence, including our own1, shows the plasma membrane encodes, amplifies, and feeds back on these extracellular cues. How can a compositionally heterogeneous fluid bilayer process information? We find that upon integrin activation, cells generate localized mesoscale liquid-ordered membrane domains (“active emulsions”2) downstream of RhoA signaling and mechanotransduction1. These domains encode substrate chemistry and mechanics, regulating integrin function, cell spreading, and migration. Such organization arises from engagement with myosin motors, a dynamic cortical actin meshwork, and actively maintained bilayer asymmetry, creating an ATP-fueled, mechano-responsive medium integrating peripheral cues. 1. PMID: 31104842; 2. PMID: 35867835
