Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Both the ENCODE and TCGA projects highlighted the value of quantifying multiple biomarker classes (DNA, RNA, and protein) from cancer tumor samples. In the case of cancer immunotherapy, the importance of measuring non-DNA markers (e.g., mRNA and proteins) becomes crucial since cell signaling, tumor microenvironment, and protein-protein interactions dominate over pure SNP-based (DNA) driver mutations in determining therapeutic response. Combining multiple data types together into a single correlated analysis, however, is adversely effected by the drastically different methodologies utilized for measurement. For example, the fluorescence signal intensity obtained from a camera imaging a protein array (e.g., RPPA) is very difficult to correlate directly with an RNA sequencing count of a clonally amplified, cDNA-converted, mRNA molecule. New developments in multiple biomarker-class optical barcode counting significantly reduce this problem. Recent developments using NanoString Technology has shown how optical barcode technology can be utilized for multiplexed digital counting of proteins and be combined with simultaneous digital counting of nucleic acids on a single platform.
