Regulation of human pluripotent stem cell differentiation by the cell cycle
Siim Pauklin studies the molecular mechanisms that govern human pluripotent stem cell self-renewal and differentiation, particularly their specification to endoderm and to pancreatic insulin-producing beta-cells. He is interested in the function of TGFß / Activin / Nodal signalling pathway in these processes, since this pathway is essential for pluripotent stem cell self-renewal and early embryonic development but is also involved in human pathologies such as pancreatic cancer and diabetes. His talk will focus on his recent discoveries on the regulation of human pluripotent stem cell differentiation (Pauklin 2013 Cell; Pauklin 2015 Genes Dev; Bertero 2015 Genes Dev). This research has uncovered important mechanisms how stem cell differentiation is orchestrated by the cell cycle.
Date: 4 November 2015, 11:30 (Wednesday, 4th week, Michaelmas 2015)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Library
Speaker: Siim Pauklin (Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organisers: Katherine McNeil (University of Oxford, Department of Physiology Anatomy and Genetics), Sarah Noujaim (University of Oxford, Department of Physiology Anatomy and Genetics), Sara Bouskela (University of Oxford, Department of Physiology Anatomy and Genetics (DPAG))
Part of: DPAG Guest Speakers
Booking required?: Not required
Audience: Members of the University only
Editor: Sara Bouskela