LRRK2 Mediated Cellular Function from Vesicular Trafficking to Gene Expression
My research has focused on two main aspects of neurobiology, the pathogenesis of Parkinson’s and trapping and accumulation of inhibitory receptors at synapses.

In my laboratory, we employ cell biological, biochemistry and proteomic techniques in an effort to:
i) discover how pathogenic mutations in PARK genes lead to neuronal death,
ii) uncover new leads for genetic analysis, and
iii) identify new therapeutic targets for disease modifying treatment.

My current research focus is on the physiological and pathological role of the Parkinson’s protein LRRK2 in Wnt signalling and cytoskeletal function. In addition, I continue to research the role of proteins important for receptor clustering such as gephyrin and collybistin in inhibitory receptor clustering and intellectual disability.
Date: 27 March 2019, 16:00 (Wednesday, 11th week, Hilary 2019)
Venue: Sherrington Library, off Parks Road OX1 3PT
Speaker: Professor Kirsten Harvey (UCL School of Pharmacy)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Melanie Witt (University of Oxford, Department of Earth Sciences, Department of Physiology Anatomy and Genetics)
Organiser contact email address: opdc.administrator@dpag.ox.ac.uk
Part of: OPDC Seminar Series (DPAG)
Topics: Degeneration (Pathology), Parkinson's disease, Pathology
Booking required?: Not required
Audience: Members of the University only
Editor: Melanie Witt