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Int'l Guest Speaker Professor Martina Muckenthaler, Heidelberg University Hospital : The role of the hepcidin/ferroportin regulatory system in health and disease
INT'L GUEST SPEAKER
Imbalances of iron homeostasis account for some of the most common human diseases. Pathologies result from both, iron deficiency or overload and frequently affect the hepcidin/ferroportin regulatory system that balances systemic iron metabolism. The small hepatic peptide hormone hepcidin orchestrates systemic iron fluxes and controls plasma iron levels by binding to the iron exporter ferroportin on the surface of iron releasing cells, triggering its degradation and hence reducing iron transfer to transferrin. Hepcidin thus maintains transferrin saturation at physiological levels assuring adequate iron supplies to all cell types.
My presentation will focus on mechanisms that control hepcidin and ferroportin expression as well as on pathologies that arise when this key regulatory circuitry underlying systemic iron homeostasis is disrupted.
Date:
11 March 2016, 13:00
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
DPAG Large Lecture Theatre, Sherrington Building, off Parks/South Parks Road, OX1 3PT T: 01865 272500
Speaker:
Professor Martina Muckenthaler ( Department of Paediatric Oncology, Haematology and Immunology, Heidelberg University Hospital)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Sarah Noujaim (University of Oxford, Department of Physiology Anatomy and Genetics)
Organiser contact email address:
sarah.noujaim@dpag.ox.ac.uk
Host:
Professor Peter Robbins (DPAG, University of Oxford)
Part of:
DPAG Head of Department Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sarah Noujaim
