A consistent feature of lung injury is a rapid and sustained accumulation of the extracellular matrix component hyaluronan (HA). Increased HA is found in the lungs after infection with SARS-CoV2 or influenza but also during asthma and allergy or exposure to pollutants. Here, I’ll present our recent work showing that the type-2 cytokine IL-13 is required for HA matrix formation in several models of lung challenge. Our aim now is to understand how IL-13 regulates these matrices and understand how HA accumulation and formation of specific HA matrices either contributes to effective tissue repair or drives lung pathology.