On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
Influenza A viruses (IAVs) are enveloped RNA viruses that cause seasonal epidemics and occasional pandemics. During the late stages of virus host cell entry the IAV particle undergoes viral capsid/shell uncoating, cytosolic release of the infectious genomic segments known as viral ribonucleoproteins (vRNPs), and nuclear import of vRNPs. Viral replication takes place in the nucleus of infected cells. Using siRNA screening and cell biology approaches we identified cellular processes that promote IAV uncoating. Here, I will introduce histone deacetylase 6 (HDAC6), a cytosolic lysine deacetylase with ubiquitin-binding activity, and transportin-1 (TNPO1), an importin that regulates liquid liquid phase separation. Both factors are key regulators of cellular disaggregation and are potentially hijacked by multiple enveloped RNA viruses to establish infection in host cells.
