On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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The concerted production of the correct number and diversity of neurons and glia is essential for intricate neural circuit assembly. In the developing cerebral cortex, radial glia progenitors (RGPs) are responsible for producing all neocortical neurons and certain glia lineages. We recently performed a quantitative clonal analysis by exploiting the unprecedented resolution of the genetic MADM (Mosaic Analysis with Double Markers) technology and discovered a high degree of non-stochasticity and thus deterministic mode of RGP behavior. However, the cellular and molecular mechanisms controlling the precise pre-programmed RGP lineage progression through proliferation, neurogenesis and gliogenesis remain unknown. To this end we use quantitative MADM-based experimental paradigms at single RGP resolution to define the non-cell-autonomous mechanisms and intrinsic functions of candidate genes controlling RGP-mediated cortical neuron and glia genesis and postnatal stem cell behavior.
For more information: zoltan.molnar@dpag.ox.ac.uk or noemi.picco@sjc.ox.ac.uk
