OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA) are highly context dependent. Rheumatoid arthritis patients often display very different patterns of local synovial pathology– termed fibroblast-rich, myeloid-rich and lymphoid-rich synovitis. My overarching goal is to identify the decision-making processes affecting the clinical presentation of these synovial pathotypes. Combining functional genomic approaches and histological studies in mice and humans I will discuss how cells within the inflamed synovium sense and interpret cytokine cues linked with these pathotypes. With a primary focus on cytokines that signal through the latent transcription factors STAT1 and STAT3, I will provide new insights into the potential role of protein tyrosine phosphatases as biological rheostats of Jak-STAT signalling within the inflamed joint.
