OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
The two-process model serves as a major conceptual framework in sleep science. I shall describe how animal experiments aimed at exploring circadian oscillators led to the recognition of a sleep-wake dependent process. Its interaction with a circadian process provided the basis of the two-process model. Simulations could account for the timing and intensity of sleep for a variety of schedules. The model has been extended to incorporate local aspects of sleep and instead of a single circadian pacemaker, multiple peripheral oscillators need to be considered. Presently, the underlying mechanisms are explored at the synaptic level as well as in the domain of the transcriptome and proteome. A close relationship between sleep and metabolism has been recognized. The original interpretation that the emergence of sleep provides an escape from the rigid control imposed by the circadian pacemaker is still upheld.
