Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
B cells and T cells are important components of the adaptive immune system and mediate anti-cancer immunity. In this talk, I will present two recent studies that harness multi-omics technologies to unveil groundbreaking insights into immune cell immunosurveillance across metastatic sites and patient-specific responses to tumours. Our research reveals a dynamic co-evolution between B and T cell immune responses and metastatic cancer genomes, with B cell clones demonstrating remarkable predictability in immunosurveillance—a finding with broad relevance across immune-mediated diseases. Using single-cell multi-omics in pancreatic cancer, we identify two distinct immune microenvironments and their driving mechanisms: myeloid-enriched (linked to poor prognosis) and adaptive-enriched (associated with robust B/T cell clonal expansion and better outcomes). This work offers a novel blueprint for prioritising antibody sequences for therapeutic development and guiding rational combination immunotherapies, paving the way for more effective, personalised cancer treatments.
