Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Specificity and efficacy in intracellular signal transduction can be conferred by the anchoring and co-localization of key enzymes and their upstream activators and substrate effectors by scaffold proteins. The Kapiloff lab studies how signalosomes organized by scaffold proteins regulate cellular function in the heart and eye, in particular regarding pathological cardiac myocyte hypertrophy and retinal ganglion cell neuroprotection. A major focus of our laboratory has been the characterization of multimolecular signaling complexes organized by the scaffold protein mAKAPβ located at the nuclear envelope in cardiac myocytes. Our research into the mechanisms of mAKAPβ signalosome function has evolved now into the preclinical development of mAKAPβ-targeted gene therapy for the prevention of heart failure. Separately, research has revealed a new mechanism for calcineurin Aβ-specific anchoring that confers compartmentation specific for the regulation of cardiac hypertrophy.
