Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
DNA replication onset requires the orchestrated action of multiple enzymes that often function as large, modular assemblies. To describe the architecture and dynamics of the eukaryotic DNA replication machinery, we combine biochemistry and single-particle cryo-electron microscopy to elucidate the mechanics of replication origin activation and fork progression. Using these tools we have recently gained important novel insights into the mechanism of DNA translocation by the replicative helicase, CMG. We have also described the physical link between the CMG helicase and the Polymerase alpha component of the lagging strand primosome, starting to explain how DNA unwinding and synthesis are coupled during genome duplication. Our results help establish a molecular framework to explain how eukaryotes respond to DNA damage and how cell proliferation is regulated to avoid tumorigenesis.
