OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Our guts are home to a complex, dense and dynamic consortia of microbes, which can have a profound impact on our health. In this presentation, we will discuss how the mucosal immune system has evolved to minimize the risk from opportunistic bacterial pathogens such as Salmonella and E.coli. This requires us to explore secretory antibody function, intestinal physiology, bacterial glycobiology, within-host evolution and microbial ecology of the gut. A functional understanding of these systems reveals the potential for oral vaccine-based interventions that allow elimination of pathogen carriage (3, 4), with potential to expand into rational microbiota engineering.
1. High-avidity IgA protects the intestine by enchaining growing bacteria. Moor K, et al. 2017. Nature 544:498–502 doi:10.1038/nature22058
2. Inflammation boosts bacteriophage transfer between Salmonella. Diard M, et al. 2017. Science 355:1211-1215, doi:10.1126/science.aaf8451
3. A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.Diard M, et al. Nat Microbiol. 2021 May 27. doi:10.1038/s41564-021-00911-1.
4. Vaccine-enhanced competition permits rational bacterial strain replacement in the gut. Lentsch V. et al. Accepted in Science 2025. bioRxiv doi.org/10.1101/2022.07.20.498444
