Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Chemokines are the master regulators of leukocyte trafficking in inflammation. However, effectively targeting chemokines in inflammatory disease therapy requires agents that selectively block several chemokines. Ticks express salivary proteins (evasins) that inhibit chemokines, broadly suppressing host inflammation and supporting blood feeding. The structures of “Class A” evasins bound to chemokines, supported by mutational analyses, revealed the basis of their specificity for CC chemokines as well as features that control their selectivity amongst CC chemokines. These structural insights enabled rational engineering of evasins to tailor their chemokine selectivity. These studies provide a basis for development of evasins with applications in anti-inflammatory therapy.
