Abstract: Human leucocyte antigens (HLAs) bind peptide fragments for recognition by T-cell receptors. An individual’s HLA genotype determines which specific pathogen peptides their T cell responses are able to target. It is widely accepted that HLAs and various human pathogens must co-evolve, and that this accounts for the extraordinarily high HLA polymorphism seen across human populations. I use mathematical models and individual-based computational simulations to understand HLA/pathogen co-evolution. I will present general predictions about the population genetic signatures of pathogen selection we might expect to find among HLA loci, as well as discussing a model motivated specifically by Plasmodium falciparum malaria.

Bio: Bridget Penman studies the genetics of infection. She uses mathematical and computational models to simulate interactions between pathogens and genetically diverse host species. Bridget is especially interested in malaria parasites and in how humans and other primates have adapted to malaria. Bridget studied her undergraduate degree and DPhil at Oxford and was also a postdoctoral fellow in the Zoology department and at Merton College. She then moved to the University of Warwick, where she worked in the School of Life Sciences and the Zeeman Institute. Bridget is now an Associate Professor Tutorial Fellow in the Biology Department and St Peter’s College here in Oxford.