On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
Fine control of immune cell activation is critical for preventing inflammatory disease, particularly in barrier sites such as the lung. However, the central mechanisms involved in controlling pulmonary macrophages and dendritic cells (DCs) during type-2 inflammation are currently poorly understood. We have found that the lung environment dramatically impairs the ability of alveolar macrophages to respond during type-2 inflammation following administration of IL-4 complex (IL-4c), allergen exposure or helminth infection, and identified which DC subpopulations are associated with induction of type-2 outcomes in such settings. Together, our data provide novel insight into the fundamental mechanisms that control macrophage and DC activation and function during pulmonary type-2 inflammation.
