Mechanotransduction was perhaps the last major sensory modality not understood at the molecular level. Proteins/ion channels that sense mechanical force are postulated to play critical roles in sensing touch/pain (somatosensation), sound (hearing), shear stress (cardiovascular function), etc.; however, the identity of ion channels involved in sensing mechanical force had remained elusive. The Patapoutian lab identified PIEZO1 and PIEZO2, mechanically-activated cation channels that are expressed in many mechanosensitive cell types. Genetic studies established that PIEZO2 is the principal mechanical transducer for touch, proprioception, baroreception and bladder & lung stretch, and that PIEZO1 mediates blood-flow sensing, which impacts vascular development and iron homeostasis. Clinical investigations have confirmed the importance of these channels in human physiology.

SPEAKER BIOGRAPHY

Ardem Patapoutian is an American scientist of Armenian origin. He is molecular biologist specializing in sensory transduction. His research has led to the identification of receptors activated by temperature and pressure. His laboratory has shown that these ion channels play crucial roles in sensing temperature, touch, proprioception, pain, and blood presssure. Patapoutian was born in Lebanon in 1967 and attended the American University of Beirut for one year before he immigrated to The United States in 1986 and became a US citizen. He graduated from UCLA in 1990 and received his Ph.D. at Caltech in 1996. After postdoctoral work with Dr. Lou Reichardt at UCSF, he joined the faculty of Scripps Research in 2000, where he currently holds the Presidential Endowed Chair and is a Professor in the Department of Neuroscience. Patapoutian was awarded the Young Investigator Award from the Society for Neuroscience in 2006 and was named an Investigator of the Howard Hughes Medical Institute in 2014. He is a fellow of the American Association for the Advancement of Science (2016), a member of the National Academy of Sciences (2017) and a member of American Academy of Arts and Sciences (2020). He is a co-recipient of the 2017 Alden Spencer Award from Columbia, the 2019 Rosenstiel Award for Distinguished Work in Basic Medical, the 2020 Kavli Prize in Neuroscience, and the 2021 Nobel Prize in Physiology or Medicine.