OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
There has been significant interest in defining mechanisms of microbiome-immune system crosstalk and its influence on therapy. We have identified a key role for tryptophan-derived microbial metabolites in induction of an immune-suppressive program in tissue-resident macrophages that attenuates T cell function promoting tumor growth. In this seminar I will describe mechanisms that are essential for microbiome-innate immune crosstalk, potential avenues of therapeutic intervention in this regulatory circuit, as well as recent developments in the field that reveal the challenging complexity of bacterial tryptophan metabolization, disease pathology, and the response to a variety of therapeutic modalities.
