OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected to start before the end of Hilary Term to allow all future events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed on the Staff Gateway and via email to identified OxTalks users.
If you have any questions, please contact halo@digital.ox.ac.uk
There has been significant interest in defining mechanisms of microbiome-immune system crosstalk and its influence on therapy. We have identified a key role for tryptophan-derived microbial metabolites in induction of an immune-suppressive program in tissue-resident macrophages that attenuates T cell function promoting tumor growth. In this seminar I will describe mechanisms that are essential for microbiome-innate immune crosstalk, potential avenues of therapeutic intervention in this regulatory circuit, as well as recent developments in the field that reveal the challenging complexity of bacterial tryptophan metabolization, disease pathology, and the response to a variety of therapeutic modalities.
