Niche engineering drives early passage through an immune bottleneck in progression to colorectal cancer

Chandler received his Masters is Biological Anthropology at the University of Utah, followed by a Ph.D in Biology at the University of Louisville. He is a Research Scientist whose work is focused on tumor-immune eco-evolutionary dynamics. He uses population models, agent based models, and evolutionary game theory to study how tumors evolve the ability to escape immune predation, and the subsequent treatment implications. This is complemented by the development of tools to process and analyse histology. Ecological analyses can be conducted on the data collected by these tools, and the findings can be used to inform and verify modelling decisions and predictions, respectively. It is hoped that the integration of modelling and data will produce actionable insights that can be used treat, and ideally prevent, cancer.