OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
In the dynamic field of biomedical engineering and immunotherapy, my recent research unveils the intricate relationship between mechanical forces and immune cell activation, bridging the realms of biology and immunotherapy. This study aims to unearth innovative pathways for adoptive immunotherapies, emphasizing the role of biomedical and mechanobiological insights in broadening our understanding.
The core focus lies in decoding the mechanobiological pathways governing T cell and B cell activation. It explores the interplay between external mechanical cues and the immune cell activation process, with a nod to biomedical concepts for fresh perspectives. In my presentation I will focus on links between mechanical cues, gene expression profiles, and the spatial organization of genomic loci and transcripts within immune cells. Combining optical super-resolution imaging, traction force and molecular force microscopy with functional read-outs – such as single cell transcriptomics and mitochondrial activity – opens possibilities for quality control in chimeric antigen receptor T (CAR-T) cell therapy, with potential applications in clinical contexts.
This interdisciplinary approach holds the potential to revolutionize adoptive immunotherapies, incorporating insights from biomedical and life sciences.
