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Chronic hepatitis B virus (HBV) infection presents a significant global health challenge, characterized by substantial morbidity and mortality rates worldwide. Despite the existence of a preventive vaccine, current treatment options offer limited efficacy in clearing the virus, necessitating lifelong management. The diagnosis and prognosis of HBV heavily rely on its surface antigen (HBsAg). However, despite extensive research efforts, detailed high-resolution structures of HBsAg and its assembly on the virus envelope have remained elusive.
We have employed sophisticated strategies and advanced computational tools to uncover the near-atomic resolution structure of HBsAg and its assembly.
