OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Centrosomes are small cytoplasmic organelles that generate and organize microtubule networks, and thus contribute to a multitude of cellular processes including cell division, polarity and trafficking. For instance, centrosomes drive mitotic spindle assembly whilst cytolytic immune cells depend on centrosomal microtubule arrays for the targeted release of secretory lysosomes. Emerging evidence suggests that centrosomes also act as signalling hubs; due to their membraneless nature, these organelles are able to concentrate (and possibly scaffold) components of signalling pathways from the cytosol. Furthermore, in many cell types, centrosomes template assembly of the primary cilium, an antenna-like cell surface organelle with prominent roles in Hedgehog, Wnt and Notch signalling. To fulfil these complex roles, cells must accurately control centrosome number, composition, structure and function. My group combines cell biology, super-resolution and live microscopy, mouse genetics and proteomics to determine physiological roles and regulation of centrosomes, and to probe the impact of centrosome aberrancies on human pathologies.
