OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Super-resolution methods present a true game changer for the field of correlative light and electron microscopy (CLEM). They allow bridging the big resolution gap between conventional fluorescence microscopy (FM) and electron microscopy (EM). Cryo-immobilisation by fast-freezing techniques has been introduced to allow imaging in vitreous (glass-like) biological samples with superior structural preservation. On the one side, cryo-EM has evolved into a routine method for structural biology. Particularly cryo electron tomography (cryo-ET) offers insights into intact cells at unprecedented resolution. On the other side, super-resolution FM under cryo-conditions is still at a very early and experimental stage. However, the combination of both cryo-microscopy methods has great potential to open up a wide range of new application possibilities in structural and cellular biology. In my talk, I will discuss the challenges, our current solutions and the prospects for super-resolution cryo-CLEM.
