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Dr Pauklin studies the molecular mechanisms that govern the stem cell identity of human pluripotent stem cells, and their relevance to tumorigenic processes. He is particularly interested in the function of TGFß/Nodal-Smad2/3 signalling pathway, which has a central role in maintaining pluripotent stem cells and cancer stem cells. Dr Pauklin’s talk will focus on his recent discoveries on cell cycle and epigenetic mechanisms that regulate the self-renewal and differentiation of human pluripotent stem cells (Pauklin 2013 Cell; Pauklin 2016 Genes Dev; Bertero 2015 Genes Dev).
