OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Intracellular pathogens colonize specific subcellular niches, determined by their need for host-derived nutrients and their ability to overcome compartment-specific immune responses. Most intracellular bacteria reside in phagosomes, with only a few species managing to colonize the cytosol. This is somewhat counterintuitive, given the abundance of nutrients freely available in the cytosol. Therefore, potent cytosolic defense mechanisms must exist. I will discuss how cells protect their cytosol against bacterial invasion through autophagy, focusing on novel triggers for antibacterial autophagy that we have discovered: the detection of sphingomyelin on damaged phagosomes by TECPR1, and the ubiquitylation of LPS on Gram-negative bacteria by RNF213. I will also explore how cytosol-adapted bacteria counteract antibacterial autophagy
