On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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Intracellular pathogens colonize specific subcellular niches, determined by their need for host-derived nutrients and their ability to overcome compartment-specific immune responses. Most intracellular bacteria reside in phagosomes, with only a few species managing to colonize the cytosol. This is somewhat counterintuitive, given the abundance of nutrients freely available in the cytosol. Therefore, potent cytosolic defense mechanisms must exist. I will discuss how cells protect their cytosol against bacterial invasion through autophagy, focusing on novel triggers for antibacterial autophagy that we have discovered: the detection of sphingomyelin on damaged phagosomes by TECPR1, and the ubiquitylation of LPS on Gram-negative bacteria by RNF213. I will also explore how cytosol-adapted bacteria counteract antibacterial autophagy
