OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Microglia are the main resident immune cells in the central nervous system. The expansion and activation of microglia is a hallmark of many neurodegenerative diseases including Alzheimer’s disease or prion disease. Colony-stimulating factor 1 receptor (CSF1R) is involved in the control of the microglial proliferation and can be activated by two independent ligands, CSF1 and IL-34. These two ligands display differences in the signalling cascade suggesting a complementary role. However, although CSF1 and IL-34 are expressed in many organs, IL-34 appears particularly expressed in the developing and adult brain, suggesting that maintenance of the populations of microglia is dependent on IL-34-CSF1R signaling. The aim of this project is the evaluation of novel strategies that can be used to modulate microglia proliferation in neurodegenerative diseases by using an in vivo model of neurodegeneration (prion disease; ME7).
