The mechanics of semaphorin-plexin cell guidance signalling

Yvonne’s group studies the structural biology of extracellular signalling complexes. Using a integrative approach of protein crystallography, light and electron microscopy, and cell-based assays, they hope to address fundamental questions about the cell-cell signalling of systems relevant in health and disease. Some of their recent work examines the cell-cell communication mediated between semaphorin ligands and plexin receptors, which are important in cell guidance in developing neuronal cells.