On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
X chromosome inactivation (XCI) generates clonal heterogeneity within XX individuals. Combined with sequence variation between human X chromosomes, XCI gives rise to intra-individual clonal diversity, whereby two sets of clones express mutually exclusive sequence variants present on one or the other X chromosome. Here we ask whether such clones merely co-exist, or potentially interact with each other to shape the contribution of X-linked diversity to organismal development. To address this question, we focus on X-linked coding variation in the human STAG2 gene. Stag2variant clones contribute to most tissues at the expected frequencies, but fail to form lymphocytes in Stag2wild-type Stag2variant mouse models. Unexpectedly, the absence of Stag2variant clones from the lymphoid compartment is due not solely to cell-intrinsic defects, but requires continuous competition by Stag2wild-type clones. These findings show that interactions between epigenetically diverse clones, which may operate in any XX individual, can shape the contribution of X-linked genetic diversity to specific cell types and tissues.
